Beneficial effect of matching at the HLA-A and -B amino-acid triplet level on rejection-free clear graft survival in penetrating keratoplasty1

Autor: Böhringer, Daniel, Reinhard, Thomas, Duquesnoy, René J., Böhringer, Stefan, Enczmann, Jürgen, Lange, Peter, Claas, Frans, Sundmacher, Rainer
Zdroj: Transplantation; February 2004, Vol. 77 Issue: 3 p417-421, 5p
Abstrakt: The beneficial effect of human leukocyte antigen (HLA) matching on long-term prognosis in penetrating keratoplasty is now unequivocal but has to be weighed against the additional waiting period on an individual basis. HLAMatchmaker is a molecularly based algorithm for histocompatibility determination that can identify immunologically acceptable mismatches and thus potentially reduce time on the waiting list dramatically without negatively affecting prognosis.
Databáze: Supplemental Index