Assessment of a Novel Two-Component Enzyme Preparation for Human Islet Isolation and Transplantation

Autor: Bucher, Pascal, Mathe, Zoltan, Morel, Philippe, Bosco, Domenico, Andres, Axel, Kurfuest, Manfred, Friedrich, Olaf, Raemsch-Guenther, Nicole, Buhler, Leo H., Berney, Thierry
Zdroj: Transplantation; January 2005, Vol. 79 Issue: 1 p91-97, 7p
Abstrakt: Biologic characteristics of enzyme products used for islet isolation are critical for the success of islet transplantation. In particular, lot-to-lot variability significantly affects the yields of the isolation procedure. In this study, we have evaluated a new enzyme preparation in which highly purified collagenase can be blended with separately supplied neutral protease in a predetermined ratio.
Databáze: Supplemental Index