Matching of the Minor Histocompatibility Antigen HLA-A1/H-Y May Improve Prognosis in Corneal Transplantation

Autor: Böhringer, Daniel, Spierings, Eric, Enczmann, Jürgen, Böhringer, Stefan, Sundmacher, Rainer, Goulmy, Els, Reinhard, Thomas
Zdroj: Transplantation; October 2006, Vol. 82 Issue: 8 p1037-1041, 5p
Abstrakt: Minor histocompatibility (H) antigens are peptides of allelic intracellular proteins that play an important role in human leukocyte antigen (HLA) matched transplantations. In an animal model of keratoplasty, minor H antigens have even been reported to exceed the immunogenicity of major H antigens (MHC). This investigation is to assess any benefit of matching the broadly expressed gender (H-Y) and HA-3 antigens in HLA-A1 donor positive human keratoplasty.
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