| Autor: |
HERBORT, CARL P., SMET, MARC D. DE, ROBERGE, FRANCOIS G., NUSSENBLATT, ROBERT B., FITZGERALD, DAVID, LORBERBOUM-GALSKI, HAYA, PASTAN, IRA |
| Zdroj: |
Transplantation; September 1991, Vol. 52 Issue: 3 p470-474, 5p |
| Abstrakt: |
IL-2-PE40 is a recombinant chimeric protein composed of IL-2, fused to a modified pseudomonas exotoxin. This molecule is extremely toxic to activated T cells expressing high-affinity IL-2R. We used this new molecule for selective immunosuppression to treat corneal allograft rejection in the rat, using Fisher and Lewis rats, a strain combination differing only in medial and minor histocompatibility antigens. The effect of IL-2-PE40 on the immunologic response was studied using both a heterotopic corneal graft model and orthotopic grafts. At the dose of 0.31 μg/g given intraperitoneally every 12 hr, IL-2-PE40 produced a significant reduction of both total lymph node cells and cytotoxic-T-cell (CTL) activity in draining lymph nodes (DLN) of heterotopically grafted animals. IL-2-PE40 treatment also significantly reduced the clinical rejection score and cumulative rejection rate (CRR) in orthotopic grafts and appears to be a very effective immunosuppressive agent. |
| Databáze: |
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