| Autor: |
WAHLSTROM, H. E., AKIMOTO, R., ENDRES, D., KOLTERMAN, O., MOOSSA, A. R. |
| Zdroj: |
Transplantation; June 1992, Vol. 53 Issue: 6 p1190-1194, 5p |
| Abstrakt: |
We have previously demonstrated decreased insulin release and insulin resistance in dogs treated with cyclosporine (20 mg/kg/day). In this study we examine the changes caused by a lower CsA dose and evaluate the reversal of these changes. Six animals were treated for 2 weeks with oral CsA (15 mg/kg/day), after which CsA was discontinued. Glucagon stimulation tests (GST) and euglycemic clamp studies (ECS) were used to evaluate changes in insulin release and insulin resistance. GST were performed before CsA, after 2 weeks of CsA, and 3, 9, and 15 days after discontinuing CsA. ECS were performed before CsA, after 2 weeks of CsA, and 2,4, 8, and 14 days after discontinuing CsA. The mean serum CsA level after 2 weeks of treatment was 188±28 ng/ml. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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