| Autor: |
KORÁKOVÁ, LIDKA, HAŠKOVÁ, VÊRA, SVOBODOVÁ, JANA, MACUROVÁ, HELENA, SAJDLOVÁ, HELENA, IVAŠKOVÁ, EVA, HINZOVÁ, EVA |
| Zdroj: |
Transplantation; October 1975, Vol. 20 Issue: 4 p273-277, 5p |
| Abstrakt: |
Ten-fold concentrated supernatants from the 4-hr mixed cultures of lymphocytes from two humans different at two haplotypes were inoculated s.c. into the hind footpad of mice. Twenty-four to forty-eight hours later, the cellularity and the synthesis of ribonucleic acid increased significantly in the popliteal lymph nodes draining the site of injection. The supernatants from cultures of HL-A-identical cells or cells different at one haplotype lacked this activity. The results suggest that human incompatible lymphoid cells upon mutual contact liberate a soluble mediator capable of activating the draining lymph nodes, i.e., it is able to trap cells from the circulation and to stimulate them. The mediator is species-nonspecific; the activity produced by human lymphocytes can be tested on mice. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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