| Autor: |
PICKFORD, M. A., GOWER, J. D., SIMPKIN, S., SAMPSON, M., GREEN, C. J. |
| Zdroj: |
Transplantation; April 1991, Vol. 51 Issue: 4 p743-749, 7p |
| Abstrakt: |
Single orthotopic rat lung isografts were carried out in adult male AS rats after 48-hour cold storage (0°C). Grafts were preserved by simple organ flush followed by low-temperature immersion. Hypertonic citrate (HCA) without additives was evaluated as the basic flush solution. In other groups desferrioxamine (an iron chelator), verapamil (a calcium channel blocker) and prostacyclin (PGI2) were added separately to HCA and given intravenously to donor and recipient animals in an attempt to improve the preservation. Baseline controls were fresh HCA-flushed lungs grafted immediately after harvest. Negative controls to the HCA assessment were lungs flushed with isotonic saline (NaCl) stored for 48 hr at 0°C. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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