| Autor: |
ES, A. VAN, HERMANS, J., BOCKEL, J. H. VAN, PERSIJN, G. G., HOOFF, J. P. VAN, GRAEFF, J. DE |
| Zdroj: |
Transplantation; September 1983, Vol. 36 Issue: 3 p255-258, 4p |
| Abstrakt: |
In a retrospective single-center study the influence of warm ischemia time and simultaneous influence of HLA (A and B) matching on one-year renal graft survival was analyzed in 170 adult recipients of primary cadaveric renal grafts. One-year survival of grafts with warm ischemia times longer than 50 min was only 40 (n = 10). When warm ischemia time was shorter than 50 min, a 1-min increase of warm ischemia time correlated with 1 decrease in one-year graft survival as a result of rejection. This detrimental effect of warm ischemia time on graft survival was not yet significant one month after transplantation, but became more evident as follow-up time was lengthened. Warm ischemia time also correlated with the number of reversible rejection episodes in patients with a graft functioning for longer than one year (P< 0.04). The beneficial influence of HLA (A and B) matching on one-year graft survival was significant (P < 0.05 log linear test). This influence was even more evident with longer warm ischemia times. It is concluded that warm ischemia has a detrimental influence on graft survival that is mediated by rejection, and it is suggested that this might be due in part to altered presentation or expression of HLA-antigens of ischemically damaged kidney tissues. |
| Databáze: |
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