CORRELATION BETWEEN HIGHMOLECULARWEIGHT FcγRECEPTORBLOCKING FACTORS IN SERUM AND RENAL ALLOGRAFT SURVIVAL

Autor: Forwell, Margaret A., Cocker, Jane E., Peel, Moira G., Tsakiris, D. J., Briggs, J. D., Junor, B. J.R., Macsween, R. N.M., Sandilands, G. P.
Zdroj: Transplantation; August 1987, Vol. 44 Issue: 2 p227-233, 7p
Abstrakt: In this study, we have demonstrated the occurrence of IgG class noncytotoxic, lymphocyte Fc7-receptor-block-ing antibodies in a proportion of sera obtained from transfused uremic patients. The presence of these antibodies was not found to correlate with subsequent renal allograft survival. Serum fractionation studies did however reveal a striking correlation between graft survival and Fc7-receptor blocking mediated by a serum factor(s) with a sedimentation coefficient of >19S. The precise nature of this factor remains to be clarified.
Databáze: Supplemental Index