| Autor: |
SPRUCE, W. E., MCMILLAN, R., MILLER, W., FOX, R., CARSON, D., SCHWARTZ, D. B., HARTMAN, G. A., RENSHAW, L. W., BEUTLER, E. |
| Zdroj: |
Transplantation; October 1983, Vol. 36 Issue: 4 p369-371, 3p |
| Abstrakt: |
Four patients with acute leukemia received transplants from HLA-mismatched, related donors. Marrow cells that had been depleted of T lymphocytes using a monoclonal anti-T-lymphocyte antibody and rabbit complement were used. In vitro studies showed that 80–97 of the mature T lymphocytes were removed using this procedure. Infusion of the treated marrow was accomplished without complications, and engraftment occurred in each case. Graft-versus-host disease occurred in 3 of the 4 patients. These results show that additional manipulations of the marrow will be required to allow complete T lymphocyte removal from the marrow before the feasibility of this approach in HLA-mismatched patients can be determined. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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