| Autor: |
MENDES, MARIZA L., RODE, HAROLD, PERES, AMOS, KONGSHAVN, PATRICIA A. L., LAPP, WAYNE S. |
| Zdroj: |
Transplantation; April 1985, Vol. 39 Issue: 4 p418-423, 6p |
| Abstrakt: |
In this study we investigated the mechanism, or mechanisms, involved in graft-versus-host (GVH)-induced T cell immunodeficiency. Chronic GVH reactions were induced in normal CBAxA F1(BAF1) hybrid mice by the injection of parental A strain lymphoid cells. At various times (43–91 days) after GVH induction, the functional status of GVH T cells was assessed using interleukin-1 (IL-1) and interleukin-2 (IL-2) as probes. The response of GVH thymocytes to IL-1 was depressed when compared with normal thymocytes. Although GVH peanut-agglutinin-negative (PNA-) thymocytes did respond to IL-2 alone or IL-2 plus phytohemagglutinin (PHA), this response was significantly lower than the response of PNA-thymocytes from normal mice. In addition, GVH spleen cells failed to produce significant amounts of IL-2 when stimulated with concanavalin A. These results suggest that the long term immunosuppression associated with murine chronic GVH disease is due, at least in part, to a decrease in the responsiveness to IL-1 and IL-2, and to a marked deficiency in IL-2 production. |
| Databáze: |
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