| Autor: |
FISCHEL, R. J., PAYNE, W. D., GILLINGHAM, K. J., DUNN, D. L., SUTHERLAND, D. E. R., MATAS, A. J., NAJARIAN, J. S. |
| Zdroj: |
Transplantation; January 1991, Vol. 51 Issue: 1 p118-122, 5p |
| Abstrakt: |
Patients with renal transplants that survive the first year often ask about the chance of long-term function. We studied 1850 patients with primary transplants from June 7, 1963 to September 1, 1988 who had graft survival of greater than 1 year. Patients were grouped by donor type, diabetic status, and whether or not they received cyclosporine (CsA). Half-life (T1/2) was used to compare long-term survival rates. We determined the long-term graft survival inclusive and exclusive of death with function (DwF) in order to study all patients and to direct attention to immunologic losses. Pre-CsA, DwF was the major cause of graft loss in each cohort. Cause of DwF was cardiovascular (49), infection (26), and cancer (14). The percentage of patients experiencing DwF was much higher in the pre-CsA group vs. the CsA group: HLA-identical living related donor, 16 vs. 3; non-HLA-identical LRD, 22 vs. 5; and cadaver donors, 26 vs. 11. |
| Databáze: |
Supplemental Index |
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