| Autor: |
IMAGAWA, DAVID K., Millis, J. Michael, OLTHOFF, KIM M., DERUS, LESLIE J., CHIA, DAVID, SUGICH, LEE R., OZAWA, MIYUKI, DEMPSEY, ROY A., IWAKI, YUICHI, LEVY, PATRICIA J., TERASAKI, PAUL I., BUSUTTIL, RONALD W. |
| Zdroj: |
Transplantation; August 1990, Vol. 50 Issue: 2 p219-224, 6p |
| Abstrakt: |
Plasma levels of tumor necrosis factor-alpha were measured in 50 adult patients following orthotopic liver transplantation. The mean (±SEM) plasma concentration of TNF-α was significantly higher in patients experiencing a rejection episode (941±83 pg/ml) than in those with a stable clinical course (240±6 pg/ml; P=0.0001). Peak levels of TNF-α were usually found at the time of clinically diagnosed rejection, although elevated levels were observed 1–2 days earlier. First-week peak TNF-α levels were significantly higher in patients who suffered graft loss (2146±788 pg/ml) than in those who were discharged from the hospital without clinical evidence of rejection (581±93 pg/ml; P=0.004). TNF-α levels were not correlated with white blood cell count (r2=0.004), cyclosporine levels (0.01), serum creatinine (0.002), serum bilirubin (0.05), serum SGOT (0.03), or SGPT (0.05). TNF-α levels were not elevated in four cases of viral hepatitis occurring after transplantation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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