| Autor: |
Milne, Debra S., Gascoigne, Alistair D., Ashcroft, Thomas, Sviland, Lisbet, Malcolm, Archie J., Corris, Paul A. |
| Zdroj: |
Transplantation; July 1994, Vol. 57 Issue: 12 p1757-1761, 5p |
| Abstrakt: |
Twelve patients receiving lung transplants between 1988 and 1992 who developed clinical and histological features of obliterative bronchiolitis (OB) were compared with a group of 13 patients with good stable lung function (FEV1more than 80 of predicted). Histological features of 180 biopsies were studied from the first postoperative year in order to assess whether any were associated with the development of OB. Clinically and histologically defined pulmonary rejection occurring after the first month was more frequent in OB patients (P=0.03). Organizing pneumonia that was associated with acute rejection but not with nonviral infection was also seen more frequently in OB patients (P=0.003). When all available lung transplant recipients surviving beyond 18 months were included in analyses, organizing pneumonia in the first year was associated with an increased relative risk of developing OB of 2.26 (95 CL 1.19–4.29), and the occurrence of coexistent organizing pneumonia and pulmonary rejection gave a relative risk for OB of 6.33 (95 CL 1.61–24.94). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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