| Autor: |
RAMANATHAN, MURALI, LANTZ, MARIANNE, MACGREGOR, RODERICK D., HUEY, BING, TAM, SCHUMAN, LI, YING, GAROVOY, MARVIN R., Hunt, C. Anthony |
| Zdroj: |
Transplantation; February 1994, Vol. 57 Issue: 4 p612-615, 4p |
| Abstrakt: |
We report that certain oligonucleotides are capable of inhibiting cell surface induction of the major histocompatibility complex class I (MHC-I) proteins by interferon-γ in K562 cells. The inhibition by oligodeoxynucleotide 15' GGG GTT GGT TGT GTT GGG TGT TGT GT-RNH2is dose-dependent, with an EC5024 hr after dosing of approximately 4 uM for 800 U/ml interferon-γ. The reverse complement II 5' AC ACA ACA CCC AAC ACA ACC AAC CCC-RNH?did not show activity. Oligodeoxynucleotide I inhibits induction of MHC-I by interferon-γ, but does not inhibit induction by either interferon-α or interferon-β. Four other oli-godeoxynucleotides were also evaluated, and three showed activity against interferon-γ at 25 μM. |
| Databáze: |
Supplemental Index |
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