Clinical Relevance of Pretransplant Donor-Directed Antibodies Detected by Single Antigen Beads in Highly Sensitized Renal Transplant Patients

Autor: Berg-Loonen, Ella M. van den, Billen, Evy V. A., Voorter, Christina E. M., Heurn, L W. Ernest van, Claas, Frans H. J., Hooff, Johannes P. van, Christiaans, Maarten H. L.
Zdroj: Transplantation; April 2008, Vol. 85 Issue: 8 p1086-1090, 5p
Abstrakt: Highly sensitized (HS) patients (>85% panel-reactive antibodies) have a lower chance of receiving a donor kidney. Within Eurotransplant the Acceptable Mismatch (AM) program was developed to increase the chances of HS patients to receive a crossmatch-negative donor kidney. The standard crossmatch in the AM program is based on complement-dependent cytotoxicity.
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