| Autor: |
Neiman, P., Wasserman, P. B., Wentworth, B. B., Kao, G. F., Lerner, K. G., Storb, R., Buckner, C. D., Clift, R. A., Fefer, A., Fass, L., Glucksberg, H., Thomas, E. D. |
| Zdroj: |
Transplantation; May 1971, Vol. 11 Issue: 5 p478-485, 8p |
| Abstrakt: |
A retrospective analysis of interstitial pneumonia and cytomegalovirus infection CMV was carried out on a group of 50 patients undergoing marrow transplantation for hematological malignancy or aplastic anemia. Interstitial pneumonia was a serious complication of transplantation, occurring in the first 4 months following marrow engraftment in 20 patients with a fatal outcome in 14 cases. In nine patients with interstitial pneumonia there was histological, cultural, or serological evidence of infection with CMV. No other pathogen was clearly associated with any of the fatal pneumonias. Review of available data indicated a minimum of 31 of patients achieving a functional transplant showed evidence of an active CMV infection. These data also suggested that patients with poor or absent serological responses to CMV tended to develop disseminated infection with fatal pneumonia while those with marked rises in antibody titers to CMV showed either no clinical symptoms attributable to CMV or developed only transient pneumonia. A prospective study is required to confirm this observation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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