The Neutrophil The Unnoticed Threat in Xenotransplantation?

Autor: Cardozo, Lorraine A.M., Rouw, Dennis B., Ambrose, Lyn R., Midulla, Marta, Florey, Oliver, Haskard, Dorian O., Warrens, Anthony N.
Zdroj: Transplantation; December 2004, Vol. 78 Issue: 12 p1721-1728, 8p
Abstrakt: Xenotransplantation offers one way to circumvent the widening gap between the demand for and supply of human organs for transplantation, and the pig is widely regarded as the donor animal most likely to prove appropriate. Most attention has focused on the adaptive immune response to xenogeneic tissue. However, there is optimism that it may soon be possible to overcome that hurdle. In this paper, we consider the possibility of the direct recognition of xenogeneic tissue by neutrophils.
Databáze: Supplemental Index