| Autor: |
Bainbridge, D R, Brent, L, Gowland, G |
| Zdroj: |
Transplantation; July 2020, Vol. 6 Issue: 7 p849-855, 7p |
| Abstrakt: |
51Cr-labelled (A X CBA)F1strain lymph node cells were injected either i.v. or i.p. into strain A mice of three age groups adult (8-12 weeks old), “adolescent” (14 days old) and newborn (12-18 hr old). The distribution of radioactivity in various organs was studied over a period of 48 hr. Despite major similarities in the results for the three age groups, certain differences were noted (1) The effective dose to the lymphoid tissue of a body weight adjusted dose is much higher for adolescent than adult mice. After i.v. injection of cells, it was found that (2) the spleens of adult and adolescent mice lose label from 4 hr onwards, label accumulates in the spleens of newborns. (3) Some changes in the distribution of label in newborn animals resemble those following the injection of syngeneic cells into adults. After intraperitoneal injection, it was discovered that (4) changes in the distribution of label occur which can be interpreted as slower release of donor cells from the peritoneal cavity and delayed redistribution from the liver in younger animals. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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