| Abstrakt: |
Antimurine thymus sera were produced in New Zealand rabbits by 3 i.v. injections of 1 × 1099viable thymic cells from CBA/J, C57BL/6J, or A/J strain mice on three occasions at fortnightly intervals, followed by bleeding 7 days after the third injection. Groups of CBA/J and C57BL/6J mice, receiving A/J skin grafts, were treated with anti-CBA/J, anti-C57BL/6J, or anti-A/J thymus sera, or with normal rabbit serum, in two dosage schedules. The rabbit anti-A/J thymus serum also was given to A/J mice receiving C57BL/6J skin grafts. The cytotoxicity of each serum for lymphocytes from each of the strains of mice was tested in vitro and their lymphopenic effects were assessed in vivo. Strain-specific effects of the antithymus sera on the survival of skin allografts were shown when they were given in 3 doses following grafting and, perhaps, when CBA/J and C57BL/6J mice were injected daily with the anti-A/J thymus serum. No evidence for such effects could have been predicted from the cytotoxicity of the sera for lymphocytes in vitro nor from their lymphopenic effects. |
