| Abstrakt: |
Following the i.p. injection of parental strain spleen cells into F1hybrids, focal cellular infiltrates appear in the recipients' livers. The infiltrates, which are randomly distributed, can be enumerated. The total number of infiltrates per liver increases exponentially during the first 6 days and subsequently plateaus and declines. There is a reproducible relationship between the number of parental spleen cells injected and the number of infiltrates formed. Presensitization of the donor against transplantation antigens of the recipient results in increased numbers of infiltrates at all dose levels tested. Presensitization of the donor against transplantation antigens not shared by the recipient results in reduced numbers of infiltrates. The units in the donor cell suspension which are responsible for the development of the hepatic infiltrates are probably antigen-reactive cells responsive to transplantation antigen. Their numbers can be estimated. |
