| Autor: |
Hodes, Richard J., Svedmyr, Erik A. J. |
| Zdroj: |
Transplantation; May 2023, Vol. 9 Issue: 5 p470-477, 8p |
| Abstrakt: |
C57BL spleen or lymph node cells cultured for 4 days with mitomycin- treated CBA or A. CA spleen cells were tested in vitro for cytotoxicity against CBA and A.CA fibroblastic target cells. It was found that the cytotoxicity of C57BL spleen or lymph node cells toward target cells of the same genotype as those to which they had been preexposed in such a mixed leukocyte culture was greater than the cytotoxicity toward the other target cell used. This finding shows that immunologically competent cells acquire specific cytotoxicity toward H-2-incompatible target cells carrying the stimulating antigen under the conditions of the mixed culture. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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