| Autor: |
Suehadeh, I H, Guttmann, R D, Lindquist, R R, Rodriguez-Erdmann, F |
| Zdroj: |
Transplantation; January 2024, Vol. 10 Issue: 1 p75-85, 11p |
| Abstrakt: |
Modification of renal allograft rejection in rats was attempted by using drugs presumed to interfere with some secondary tissue damage reactions. Acetylsalicylic acid and sodium salicylate were used to modify platelet behavior, and heparin and bishydroxycoumarin were used to inhibit fibrin deposition. The assay system revealed, significant retention of venal function on the 7th postoperative day following treatment with acetylsalicylic acid or sodium salicylate despite the persistence of platelet aggregates and fibrin deposition m the allograft. Similarly, heparin, but not bishydroxycoumarin, in nearly lethal doses resulted in the modification of the usual pattern of allograft rejection. It is concluded that, while interference with some of the secondary effects involved in allograft rejection may alter the degree of tissue damage, control of rejection requires inhibition of primary immunological events. |
| Databáze: |
Supplemental Index |
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