A Prospective DoubleBlind PlaceboControlled Trial of a Single Dose of Azithromycin on Postoperative Wound Infections in Plastic Surgery

Autor: Amland, Petter F., Andenaes, Kjell, Samdal, Frode, Lingaas, Egil, Sandsmark, Morten, åbyholm, Frank, Giercksky, Karl-Erik
Zdroj: Plastic and Reconstructive Surgery; November 1995, Vol. 96 Issue: 6 p1378-1383, 6p
Abstrakt: Over a 9-month period from September of 1991 to May of 1992, 339 patients were included in a randomized, double-blind, placebo-controlled study using azithromycin as the prophylactic agent to determine whether it effects a clinically meaningful reduction in postoperative surgical infections in plastic surgery. Azithromycin was given as prophylaxis in 171 patients and placebo in 168 patients. The study medication was a single oral dose taken at 8 P.M. the day before surgery. The patients were followed up for a minimum of 4 weeks after surgery.
Databáze: Supplemental Index