Role of cGMP in Sildenafil-Induced Activation of Endothelial Ca(2)-Activated K() Channels

Autor: Luedders, Doerte Wiebke, Muenz, Benedikt Manuel, Li, Fang, Rueckleben, Sebastian, Tillmanns, Harald, Waldecker, Bernd, Wiecha, Johannes, Erdogan, Ali, Schaefer, Christian Alexander, Kuhlmann, Christoph Ruediger Wolfram
Zdroj: Journal of Cardiovascular Pharmacology; March 2006, Vol. 47 Issue: 3 p365-370, 6p
Abstrakt: Intracellular cGMP is an important second messenger in endothelial cells. Because Ca2-activated Kchannels with large conductance (BKCa) have been shown to regulate endothelial cell functions, the aim of the present study was to examine whether sildenafil modulates BKCaactivity in cultured human endothelial cells.
Databáze: Supplemental Index