Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy

Autor: Shankaran, Seetha, Laptook, Abbot R., Pappas, Athina, McDonald, Scott. A., Das, Abhik, Tyson, Jon E., Poindexter, Brenda B., Schibler, Kurt, Bell, Edward F., Heyne, Roy J., Pedroza, Claudia, Bara, Rebecca, Meurs, Krisa P. Van, Grisby, Cathy, Huitema, Carolyn M. Petrie, Garg, Meena, Ehrenkranz, Richard A., Shepherd, Edward G., Chalak, Lina F., Hamrick, Shannon E. G., Khan, Amir M., Reynolds, Anne Marie, Laughon, Matthew M., Truog, William E., Dysart, Kevin C., Carlo, Waldemar A., Walsh, Michele C., Watterberg, Kristi L., Higgins, Rosemary D.
Zdroj: Obstetrical and Gynecological Survey; April 2015, Vol. 70 Issue: 4 p235-238, 4p
Abstrakt: Hypoxic ischemic encephalopathy (HIE) due to acute perinatal asphyxia is 1 cause of childhood neurodevelopmental deficits among term infants. Induced hypothermia can decrease death or disability, but rates of death or disability remain at 44 to 55. This multicenter randomized clinical trial among infants with moderate or severe HIE was performed to evaluate the safety and effectiveness of deeper cooling, longer cooling, or both.
Databáze: Supplemental Index