Low-Fat Dietary Pattern and Risk of Invasive Breast Cancer The Women’s Health Initiative Randomized Controlled Dietary Modification Trial

Autor: Prentice, Ross L., Caan, Bette, Chlebowski, Rowan T., Patterson, Ruth, Kuller, Lewis H., Ockene, Judith K., Margolis, Karen L., Limacher, Marian C., Manson, JoAnn E., Parker, Linda M., Paskett, Electra, Phillips, Lawrence, Robbins, John, Rossouw, Jacques E., Sarto, Gloria E., Shikany, James M., Stefanick, Marcia L., Thomson, Cynthia A., Van Horn, Linda, Vitolins, Mara Z., Wactawski-Wende, Jean, Wallace, Robert G. B., Wassertheil-Smoller, Sylvia, Whitlock, Evelyn, Yano, Katsuhiko, Adams-Campbell, Lucile, Anderson, Garnet L., Assaf, Annlouise R., Beresford, Shirley A. A., Black, Henry R., Brunner, Robert L., Brzyski, Robert G., Ford, Leslie, Gass, Margery, Hays, Jennifer, Heber, David, Heiss, Gerardo, Hendrix, Susan L., Hsia, Judith, Hubbell, F Allan, Jackson, Rebecca D., Johnson, Karen C., Kotchen, Jane Morley, LaCroix, Andrea Z., Lane, Dorothy S., Langer, Robert D., Lasser, Norman L., Henderson, Maureen M.
Zdroj: Obstetrical and Gynecological Survey; July 2006, Vol. 61 Issue: 7 p454-456, 3p
Abstrakt: Despite a longstanding belief that a low-fat diet can reduce the risk of breast cancer, no controlled intervention trials have been reported. This randomized, controlled, primary prevention trial, based on the Women’s Health Initiative cohort, enrolled 48,835 postmenopausal women 50 to 79 years of age at 40 U.S. clinical centers in the years 1993–2005. Forty percent of participants received a diet designed to lower the intake of total fat to 20% of energy, provide at least 5 servings daily of fruit and vegetables, and include at least 6 daily servings of grains. There was no explicit weight loss goal. The remaining 60% of women continued on their usual diets. The intervention group took part in an intensive behavioral modification program administered by a specially trained nutritionist. Participants received an individualized goal of total fat grams based on height and were trained to monitor their dietary intake. The comparison women were given informational materials, including dietary guidelines.
Databáze: Supplemental Index