| Autor: |
Schnabelrauch, Matthias, Dubs, Manuela, Kautz, Armin R., Weisser, Juergen, Bergemann, Claudia, Rebl, Henrike, Schmidt, Jürgen, Witt, Carolin, Oberbach, Thomas, Imhof, Diana, Nebe, J. Barbara |
| Zdroj: |
Materials Science Forum; December 2018, Vol. 941 Issue: 1 p2483-2488, 6p |
| Abstrakt: |
Surface biofunctionalization is a common strategy to improve the material-tissue interface of inert implant surfaces. In this context we coated alumina-toughened zirconia (ATZ) ceramics after titanium plasma spraying with two different porous calcium phosphate layers and subsequently functionalized the obtained surfaces either with an RGD containing cell adhesion peptide sequence or a bone morphogenetic protein (BMP)-glycosaminoglycan complex. We studied initial cell adhesion densities, integrin expression, and alkaline phosphatase activity as an osteogenic marker of the coatings in vitro in comparison to the non-functionalized ATZ ceramics to evaluate the bone ingrowth potential of these biofunctionalized implant coatings. |
| Databáze: |
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