| Autor: |
kageyama, Masaaki, Nishimura, Kazuo, Takada, Toyokazu, Miyawaki, Nobuaki, Yamauchi, Hideyasu |
| Zdroj: |
Journal of Cardiovascular Pharmacology; January 1991, Vol. 17 Issue: 1 p102-107, 6p |
| Abstrakt: |
We compared the effects of SD-3211, a novel calcuim antagonist, on blood pressure, heart rate, and atrioventricular conduction with those of diltiazen usinng conscius renal hypertensice dogs (one-kidney, one-clip type). We also examined the combined effects of these calcium antagonists with a beta-adrenceptor antagonist. propranolo, on these variabes. Oral administration of SD-3211 (1.25. 2.5 and 5 mg/kg) resulted ion a dosedependent decrease in blood pressure without affecting heart rate. SD-3211 at all three doses significantly decreased systolic blood pressure. At 2.5 and 5 mg/kg the compound elicited significant decreases in mean blood presure and diastolic blood pressure. Hypotension obtained with the highest dose of SD-3211 lasted for at least 9 h. No significant alteration in PR interval was observed in electrocardiograms after administration of SD-3211. Diltiazem, given orally at doses of 2.5 and 5 mg/kg but not 1.25 mg/kg, produced significant hypotension with little change in heart rate. The duration of hypotension induced by the highest dose of dilitiazem was only 3 h. Diltiazem prolonged PR interval in a dose-dependent manner, causing second-degree atrioventricular block in some dogs. Combined adminstration of SD-3211 or diltiazem (2.5 mg/kg) with propranolol (30 mg/kg) resulted in enhanced hypotension with no alteration in heart rate. SD-3211 plus prolpranolol had little effect on the PR interval, whereas diltiazem plus propranlol caused a markedly enhanced prolongation. These results indicate that SD-3211 is an antihypertensive agent with long-lasting action and little effect on heart rate and atrioventricular conduction with propranolol. may be useful in the treatment of hypertension. |
| Databáze: |
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