| Autor: |
Tobe, Tom J. M., Langen, Cees D. J. de, Tio, Rene A., Bel, Klaas J., Mook, Piet H., Wesseling, Harry |
| Zdroj: |
Journal of Cardiovascular Pharmacology; April 1991, Vol. 17 Issue: 4 p600-607, 8p |
| Abstrakt: |
In this study, the effect of brady kinn on saline infusion during isehemia and reperfusion on electrical stability 2 weejs after nt icarcra, infaction, was assessed Acute mvocardial infarction was increced in 23 Pigs by at transiummal occlusion of the left coronary artery with of catheter balloon, intlated for 48 min. Bradskinn was administered by a 30 min infustion that started after 30 min of coronary occlusion adn was continued and 15 min after reperfusion. Although creatine kinase levels in bradykinn-treated annuals were signticantly lower (p 0.001) 2 week survival was not different between groups In survivors the filtered QRS ventricular deflection ducation detected asing signal-ever aged electrocardiographys was significantly prolonged in Saline-treated pags. whereas in bradskinn- treated pigs this prolongasion was prevented. The terminal voltage of the QRS complex was significantly lower in dline-treated pigs than in bradvkinin treated pigs. These two parameters signify an improved electrical stability after bradykinin treatment. Refractory periods in Sahne-treated hearts were longer than in bradskimn-treated hearts (106 ± 10) vs 95 ± 13 (p 0.05) Also. current thresholds in the intaret border zones showed a greater varianc e in saline-treated hearts (p 0.001) pointing toward mor tissue beterogeneity of the infared border zone. Programmed electrical stimulation showed a trend toward reduced inducibility of sustained ventricular tachycardia in bradykinin treated hearts. Therefore, bradvkinin improves electrical stability 2 weeks after expermental myocardial infarction. |
| Databáze: |
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