| Autor: |
Langen, Cees D. J. de, Gilst, Wiek H. van, Wesseling, Harry |
| Zdroj: |
Journal of Cardiovascular Pharmacology; September 1985, Vol. 7 Issue: 5 p924-928, 5p |
| Abstrakt: |
The effects of iloprost (ZK 36 374) on myocardial ischemia and infarction were studied in three groups of four anesthetized and heparinized pigs. Coronary microembolization was evoked by the injection of microspheres (50 μM) into the left coronary artery. A dose of 12 million beadskg was followed by ventricular fibrillation and death after 11 ± 5 min (group A). In group B, ischemia was evident at 15 min after the injection of 6 million beadskg from an ST segment elevation in the precordial electrocardiogram (2.9 ± 1.1 mV; p < 0.05) and from an arterial-coronary venous difference in inosine concentration of −8.5 ± 0.3 μM(p < 0.05). However, in the presence of iloprost—an infusion of 0.18 μgkgmin started 30 min before embolization—no ST segment elevation (0.45 ± 0.23 mV; NS) or inosine release (−1.5 ± 1.0 μM) was detected after the injection of 12 million beadskg (group C). After 7 days, the animals from group B had more frequent spontaneous ventricular arrhythmias than those from group C. Programmed electrical stimulation induced intraventricular reentry in some animals of both groups (3 of 4 in B and 2 of 4 in C). Ventricular tachycardia was induced in two animals from group B. Postmortem examination revealed small myocardial infarcts in all group B animals; however, in group C no infarcts were detected. These data corroborate the view that prostacyclin-mimetic compounds are beneficial in the acute and in the chronic phases of myocardial infarction. |
| Databáze: |
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