| Autor: |
Obayashi, Satoshi, Beppu, Masashi, Aso, Takeshi, Goto, Moritaka, Azuma, Hiroshi |
| Zdroj: |
Journal of Cardiovascular Pharmacology; August 2001, Vol. 38 Issue: 2 p240-249, 10p |
| Abstrakt: |
These experiments were designed to investigate whether 17estradiol E2modulates the endothelial function of perimenopausal human uterine arteries. After the artery specimen was cultured in the presence or absence of E2at a physiologic concentration of 200 pgml, changes in isometric tension and cyclic nucleotide production were determined. Degree of intimal hyperplasia was assessed histologically and expressed as intimatomedia ratio. Acetylcholine produced an endotheliumdependent relaxation in six specimens group I of 12, which was inhibited by NGnitroLarginine or indomethacin. However, the agonist failed to produce a definite relaxation in the remaining 6 group II. The endotheliumdependent relaxation was significantly augmented after incubating with E2only in group I specimens. Cyclic nucleotide production was significantly increased after E2incubation only in group I specimens, whereas it was inhibited by NGnitroLarginine or indomethacin. Histologic study revealed that the six specimens of group I had normal intima intimatomedia ratio 19.1 ± 1.8 and the remaining six of group II had intimal hyperplasia intimatomedia ratio 53.6 ± 5.3. Increased production of cyclic nucleotides occurred in uterine arteries with normal intima but not in arteries with intimal hyperplasia derived from perimenopausal women. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
