| Autor: |
Rebeck, G. W., Perls, T. T., West, H. L., Sodhi, P., Lipsitz, L. A., Hyman, B. T. |
| Zdroj: |
Neurology (Ovid); August 1994, Vol. 44 Issue: 8 p1513-1516, 4p |
| Abstrakt: |
Recent genetic studies show that the apolipoprotein E 4 allele (ApoE- 4) is a risk factor for Alzheimer's disease (AD). If ApoE- 4 individuals develop AD as they get older, we would expect a decrease in ApoE- 4 allele frequency with increasing age. We found a marked decline in ApoE- 4 allele frequency with advancing age in both AD and cognitively normal controls (p< 0.003), although in all age groups the ApoE- 4 allele was overrepresented (p< 0.0001). Nonetheless, a few cognitively normal nonagenarians were ApoE- 4 positive. Thus, our data support two new conclusions: (1) the ApoE- 4 associated risk for AD is age-dependent, probably due to censoring by the earlier development of AD in ApoE- 4 individuals, and (2) despite the ApoE- 4 associated risk for AD, it is possible to reach extreme old age with normal cognition. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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