| Autor: |
Tan, N C.K., Heron, S E., Scheffer, I E., Pelekanos, J T., McMahon, J M., Vears, D F., Mulley, J C., Berkovic, S F. |
| Zdroj: |
Neurology (Ovid); September 2004, Vol. 63 Issue: 6 p1090-1092, 3p |
| Abstrakt: |
Alteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC genotype and drug-resistant epilepsy. The authors suggest the initial association may have arisen by chance. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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