MRI-guided, open trial of abciximab for ischemic stroke within a 3- to 24-hour window

Autor: Mitsias, P D., Lu, M, Silver, B, Morris, D, Ewing, J R., Daley, S, Lewandowski, C, Katramados, A, Papamitsakis, N I., Ebadian, H B., Zhao, Q, Soltanian-Zadeh, H, Hearshen, D, Patel, S C., Chopp, M
Zdroj: Neurology (Ovid); August 2005, Vol. 65 Issue: 4 p612-615, 4p
Abstrakt: The authors assessed the effect of IV abciximab on early neurologic improvement and ischemic lesion growth in 29 patients with supratentorial stroke and NIH stroke scale score (NIHSSS) ≥ 4 (11.1 ± 5.9), treated within 3 to 24 (13.6 ± 5.5) hours of onset. The 48 to 72-hour NIHSSS improvement was 4.4 ± 3.2 and the 24-hour lesion growth on DWI was 23% (−50%, 103%); 7/26 (27%) patients experienced lesion size decrease. Treatment of sub-24-hour stroke with abciximab improves early post-treatment neurologic status and often attenuates ischemic lesion growth.
Databáze: Supplemental Index