| Autor: |
Silva, Delia, Dikkes, Pieter, Barnes, Medina, Lopez, Mary Frances |
| Zdroj: |
NeuroReport; October 2009, Vol. 20 Issue: 16 p1414-1418, 5p |
| Abstrakt: |
The search for therapeutic targets to prevent neurons from dying is ongoing and involves the exploration of a long list of neurotrophic factors. Insulin-like growth factor 2 (IGF2) is a member of the insulin family with known neurotrophic properties. In this study, we used Igf2knockout (Igf2−−) neonate mice to determine whether Igf2deficiency is detrimental to motor neuron survival after axonal injury. Results show that Igf2−−neonatal mice are more susceptible to motor neuron damage than Igf2mice, as they have a significantly lower percentage of motor neuron survival after a sciatic nerve transection. Neuronal survival was significantly improved in Igf2−−mice when IGF2 was administered. These results support the role of IGF2 in neonatal motor neuron survival. |
| Databáze: |
Supplemental Index |
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