| Autor: |
Zinkand, William C., Stumpo, Robert J., Thompson, Carolann, Patel, Jitendra, Pullan, Linda M. |
| Zdroj: |
NeuroReport; November 1993, Vol. 5 Issue: 2 p148-150, 3p |
| Abstrakt: |
IN primary cultures of rat cerebral cortex, N-methyl-D-aspartate causes widespread neurotoxicity. Inhibitors of the nitric oxide generating the enzyme nitric oxide synthase has been shown to attenuate the effects of N-methyl-D-aspartate in a number of neuronal systems both in vivoand in vitro.In our experiments, the nitric oxide synthase inhibitor N-nitroarginine was ineffective at blocking neurotoxicity induced by N-methyl-D-aspartate. Cyclic guanine monophosphate, known to be synthesized in response to nitric oxide was demonstrably inhibited by identical treatments with N-nitroarginine in sister cultures. We conclude that although nitric oxide is produced in response to N-methyl-D-aspartate, it is neither necessary nor sufficient for neurotoxicity. |
| Databáze: |
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