| Autor: |
Nagafuji, Toshiaki, Sugiyama, Masakazu, Muto, Atsushi, Makino, Toshihiko, Miyauchi, Tatsuo, Nabata, Hiroyuki |
| Zdroj: |
NeuroReport; July 1995, Vol. 6 Issue: 11 p1541-1545, 5p |
| Abstrakt: |
OUR newly synthesized δ-(S-methylisothioureidoJ-L-norvaline (L-MIN) was shown to have potent inhibitory effects on Ca2+-dependent and constitutively expressed neuronal nitric oxide synthase (type I NOS) when compared to other commonly recognized NOS inhibitors and produced an IC50value of 5.7 nM. By contrast, this compound exhibited more than 40-fold weaker inhibitory effects on the other NOS isoforms. Administration of L-MIN (0.1, 0.3 and lmg kg-1, i.p.) to rats immediately after 2 h middle cerebral artery occlusion and 2 h reperfusion reduced infarct size in a dose-dependent manner. These results suggest that type I NOS activation has a crucial role in the pathogenic cellular mechanisms underlying cerebral ischaemia. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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