| Autor: |
Swarzenski, Barbara C., O'Malley, Karen L., Todd, Richard D. |
| Zdroj: |
NeuroReport; January 1996, Vol. 7 Issue: 2 p573-576, 4p |
| Abstrakt: |
Neurotransmitter receptors are known to have direct roles in the modulation of neuronal morphogenesis. Previous work showed that clonal mesencephalic MN9D cells individually transfected with D2-like dopamine receptors show increased neurite outgrowth following long-term exposure to the D2-like receptor agonist quinpirole. In the current study, brief stimulation of D3receptor-expressing cells also elicited increased neurite outgrowth, which could be mimicked by the Gi/Goprotein activator mastoparan. Pretreatment with the Gi/Goprotein inhibitor pertussis-toxin blocked the quinpirole-and mastoparan-mediated increases in outgrowth. These results suggest that dopamine D3receptor stimulation has an immediate, G-protein-mediated role in neuronal morphogenesis. |
| Databáze: |
Supplemental Index |
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