| Autor: |
Farrer, Matthew J., Crayton, Lissa, Davies, Gail E., Oliver, Christopher, Powell, John, Holland, Anthony J., Kessling, Anna M. |
| Zdroj: |
NeuroReport; May 1997, Vol. 8 Issue: 7 p1645-1649, 5p |
| Abstrakt: |
GENETIC variation in the APOEgene and variation in chromosome 21 genotypes, including the APPlocus, may influence age-associated cognitive decline in adults with Down syndrome. Molecular genetic and longitudinal neuropsychological analysis was performed for 41 unrelated Caucasian individuals (mean age 48.1 ± 1.1 years (s.e.m.)) with free trisomy 21. Allele frequencies and genotype distributions were compared among subgroups with or without evidence of cognitive decline. Genetic variability at APOEand APPwas not significantly associated with evidence of cognitive decline. However, aged individuals with Down syndrome, without evidence of cognitive decline, demonstrated unusual allelic variability at D21S11. These findings are discussed in the context of current hypotheses of Alzheimer-type dementia in Down syndrome and in the general population. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
