| Autor: |
Philpot, Michael, Lewis, Keir, Pereria, Maria Luiza, Ward, Chandra, Holmes, Clive, Lovestone, Simon, Fensom, Anthony, Seller, Mary |
| Zdroj: |
NeuroReport; July 1997, Vol. 8 Issue: 11 p2613-2616, 4p |
| Abstrakt: |
THE carrier rates of a genetic marker for arylsulphatase A pseudodeficiency (ASA-PD) were determined in three series of patients with vascular dementia (VaD) or Alzheimer's disease (AD). In the first community-based sample, the 1524 95A→G mutation, which is known to be associated with ASA-PD, was present in 35 of VaD cases and none of the AD cases. In a second sample of cases drawn from a Dementia Register, the mutation rates were 18 (VaD) and 16 (AD). Brain DNA from a post-mortem sample revealed the ASA-PD mutation in 60 of VaD cases and 34 of AD cases. These rates are higher than previous studies of culturally similar populations and suggest that ASA-PD may be a risk factor for dementia. |
| Databáze: |
Supplemental Index |
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