| Autor: |
Dhandapani, Krishnan M., Wade, Marlene F., Mahesh, Virendra B., Brann, Darrell W. |
| Zdroj: |
NeuroReport; February 2002, Vol. 13 Issue: 2 p239-241, 3p |
| Abstrakt: |
The aim of the current study was to determine whether basic fibroblast growth factor (bFGF), regulates the release of transforming growth factor-1 (TGF-1) from C6 glioma cells. The results of the study show that bFGF (2, 5 and 10 ngml) dose dependently induced the release of TGF-1 from C6 glioma cells, with the 10 ngml dose inducing a 2- to 3-fold increase of TGF-1 levels. This effect was evident as early as 6 h following treatment, with maximal levels observed at 18 h. The effect of bFGF was largely on latent TGF-1, and was isoform specific, as bFGF had no effect on TGF-2 release. The bFGF effect on TGF-1 was also glioma specific, as no such stimulatory effect was observed in rat cortical astrocytes. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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