| Autor: |
Collin, Maria, Bäckberg, Matilda, Önnestam, Kristin, Meister, Björn |
| Zdroj: |
NeuroReport; May 2002, Vol. 13 Issue: 7 p945-951, 7p |
| Abstrakt: |
Serotonin 5hydroxytryptamine 5HT is a regulator of feeding behavior. The effect of serotonin on food intake is believed to be primarily mediated via 5HT1Aand 5HT2Creceptors, which both are expressed in hypothalamic regions implicated in regulation of feeding behavior. Using an antiserum to the 5HT1Areceptor, immunoreactive neurons were observed in the rat supraoptic, paraventricular, arcuate and ventromedial nuclei and lateral hypothalamic area. 5HT1Areceptor immunoreactivity was demonstrated in neuropeptide Y, agoutirelated peptide, proopiomelanocortin and cocaine and amphetamineregulated transcriptcontaining neurons of the arcuate nucleus. In the lateral hypothalamus, 5HT1Areceptor immunoreactivity was observed in melaninconcentrating hormone and orexincontaining neurons. The results suggest that serotonin via postsynaptic 5HT1Areceptors affects the release of peptides regulating food intake. |
| Databáze: |
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