| Autor: |
Bilsland, James G., Harper, Sarah J. |
| Zdroj: |
NeuroReport; May 2003, Vol. 14 Issue: 7 p995-999, 5p |
| Abstrakt: |
CEP1347 inhibits the signalling pathway of cjunNterminal kinase, and is neuroprotective in vivo and in vitro. Embryonic chick dorsal root ganglion neurones are dependent on NGF for survival and neurite outgrowth NGF withdrawal results in apoptotic cell death. We examined the neuroprotective and neurite outgrowth promoting activity of CEP1347 in dissociated DRG neurones and in primary DRG explants. CEP1347 was as effective as NGF in promoting survival of dissociated DRG neurones, but caused only limited neurite outgrowth from DRG explants. When NGF was subsequently added to CEP1347 treated explants, the outgrowth increased to a similar level to explants which had received NGF throughout. CEP1347 may be a useful tool to maintain viable DRG explants to allow evaluation of neurite outgrowth promoting compounds and dissection of survival and neurite outgrowth signalling pathways. |
| Databáze: |
Supplemental Index |
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