| Autor: |
Armstrong, Brian D., Abad, Catalina, Chhith, Seririthanar, Rodriguez, Williams, Cheung-Lau, Gardenia, Trinh, Van, Waschek, James A. |
| Zdroj: |
NeuroReport; December 2004, Vol. 15 Issue: 17 p2647-2650, 4p |
| Abstrakt: |
PACAP is a neuropeptide with putative neuroprotective, regenerative, and immunomodulatory actions. PACAP mRNA is up-regulated in motor neurons following facial nerve axotomy in wild type, but not immunodeficient SCID mice. Because CD4 lymphocytes appear to be neuroprotective in facial nerve and other injury models, we studied PACAP gene expression in SCID mice preinfused with CD4 enriched splenocytes. Whereas the mean number of PACAP hybridizing neurons after axotomy was reduced by 75 in uninfused SCID mice, infusion of CD4 enriched splenocytes restored the number to a value not significantly different than controls. The CD4 cell-dependent induction of PACAP in motor neurons may thus be a factor in the cascade of events triggered by immune cells that ultimately lead to nerve regeneration. |
| Databáze: |
Supplemental Index |
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