| Autor: |
J$OSRGENSEN, F., ANDERSSON, B., Å. HANSON, L., NYLÉN, O., EDÉN, C. SVANBORG |
| Zdroj: |
The Pediatric Infectious Disease Journal; June 1990, Vol. 9 Issue: 6 p389-393, 5p |
| Abstrakt: |
This study examined the hypothesis that children prone to acute otitis media have a reduced concentration of circulating antibodies of the IgG2 subclass and that this defect can be compensated for by gamma-globulin treatment. Infants and children below 18 months of age with at least three episodes of acute otitis media were randomized to intramuscular gamma-globulin or no treatment and were followed for 6 months. We could demonstrate neither reduced IgG2 nor specific anti-polysaccharide antibody activity in the otitis-prone children. In contrast they had higher concentrations of IgG2 and antibodies to phosphorylcholine than did age-matched controls. There was neither a relationship between the IgG2 concentration and the number of otitis episodes prior to enrollment nor a reduction in otitis frequency in the gamma-globulin-treated group. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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