| Autor: |
KALEIDA, PHILLIP H., BLUESTONE, CHARLES D., ROCKETTE, HOWARD E., BASS, LEE W., WOLFSON, JEROME H., BRECK, JANE M., UBINGER, ELIZABETH B., ROHN, DALE D. |
| Zdroj: |
The Pediatric Infectious Disease Journal; March 1987, Vol. 6 Issue: 3 p265-271, 7p |
| Abstrakt: |
One hundred thirty-three infants and children with documented acute otitis media (OM) were randomized to receive the oral suspension of either amoxicillin-clavulanate potassium or cefaclor. Beta-lactamase-producing bacteria were found in 10.9 and 14.5 of subjects treated with amoxicillin-clavulanate potassium and cefaclor, respectively. Subjects were reexamined at 5, 10, 30, 60 and 90 days after the initiation of therapy and whenever signs/symptoms of acute otitis media recurred. All but two children had resolution of otalgia/otorrhea during the initial treatment period. The drug groups were not significantly different in the percentage of evaluable subjects with otitis media with effusion at each scheduled follow-up visit. Recurrence of acute otorrhea developed in a similar percentage of subjects in both treatment categories. Both subjects with and those without middle ear effusion at 10 days had approximately a 50 recurrence rate of subsequent middle ear disease. Adverse side effects/complaints, which occurred in significantly more children treated with amoxicillin-clavulanate potassium, were generally mild and primarily gastrointestinal. |
| Databáze: |
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| Externí odkaz: |
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