| Autor: |
NATHOO, K. J., MASON, P. R., GWANZURA, L., KOWO, H., MUBAIWA, I. |
| Zdroj: |
The Pediatric Infectious Disease Journal; October 1993, Vol. 12 Issue: 10 p840-844, 5p |
| Abstrakt: |
Postmortem blood cultures were taken from 105 neonates dying at Harare Hospital during a 1-year period. The infants were characterized by prematurity (63 <37 weeks gestation), low birth weight (60 <2500 g) and low Apgar score at 1 min (43 <3). More than one-half of the infants died within 48 hours of admission. Positive blood cultures within 10 minutes of death occurred in 44 of infants, and Klebsiellasp. were by far the most common isolates. Positive blood cultures were associated with very low birth weight (<1500 g), and with babies who survived for >48 hours. Antibodies to human immunodeficiency virus type 1 were found in 40 of the infants, and a high proportion of these had Klebsiellabacteremia. Nearly all the infants had received antibiotic therapy, usually penicillin and gentamicin. Very few babies who had received a cephalosporin had a positive blood culture, and in vitrotests showed that although many organisms were resistant to penicillin and the aminoglycosides, very few showed resistance to the cephalosporins. Our findings suggest that cephalosporins may be useful in treating severe neonatal sepsis, particularly when there is no response to more standard therapy. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
