| Autor: |
ARGUEDAS, ADRIANO G., ZALESKA, MARGARET, STUTMAN, HARRIS R., BLUMER, JEFFREY L., HAINS, CORALIE S. |
| Zdroj: |
The Pediatric Infectious Disease Journal; May 1991, Vol. 10 Issue: 5 p375-380, 6p |
| Abstrakt: |
A total of 137 children with acute otitis media with effusion were randomly allocated to treatment with cefprozil (30 mg/kg/day divided into two equal doses), an investigational cephalosporin or amoxicillin elavulanate potassium (40 mg/kg/day divided into three equal doses) for 10 days. The most common pathogens obtained from middle car cavities by tympanocentesis were Streptococcus pneumoniae(33). Haemophilus influenzae(19.6) and Moraxella catarrhalis(8.3). Patients were scheduled for follow-up visits at midtreatment, at end of therapy and at 30 days. Of the 137 children 122 were evaluable. Five of 60 patients (8.3) treated with cefprozil and 14 of 62 patients (22.5) treated with amoxicillin elavulanate potassium were considered therapeutic failures because of persistence of symptoms and/or isolation of the original pathogen or superinfection (P = 0.05), Rates of relapse, reinfection and persistent middle ear effusion as documented by tympanogram were comparable in both groups. When persistent middle ear effusion was analyzed by pneumatic otoscopy, 64 of 103 affected ears (62.1) treated with cefprozil and 80 of 105 affected ears (76.1) treated with amoxicillin elavulanate potassium were abnormal (P = 0.04). Loose stools were more common in children treated with amoxicillin elavulanate potassium than in children treated with cefprozil (P = 0.0004). Based on the efficacy results from this study, the lower gastrointestinal side effects and the convenience of twice-a-day dosing. we believe that cefprozil in a dosage of 30 mg/kg/day divided every 12 hours represents a potential alternative for the treatment of acute of it is media with effusion in children. |
| Databáze: |
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