| Autor: |
Nogueira, Christine P., Evans, David A. Price, Du, Bert N. La |
| Zdroj: |
Pharmacogenetics; June 1993, Vol. 3 Issue: 3 p144-149, 6p |
| Abstrakt: |
The paraoxonase polymorphism was analysed in the serum of 248 individuals from Saudi Arabia. The phenotyping method used was one based on the ratio of paraoxonase/arylesterase, described in earlier studies. The distribution of this ratio in the sample was trimodal and it provided a good resolution for the identification of three phenotypes: A – homozygotes with low activity; B – homozygotes with high activity; AB – the corresponding heterozygotes, with intermediate activity. Gene frequencies were 0.7296 for the allele A with low activity and 0.2704 for the allele B with high activity. These frequencies are close to those observed in Caucasian samples from North America and Europe. Phenotypic frequencies in the sample fit the Hardy-Weinberg equilibrium. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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